Lamin A/C(Phospho Ser22) Polyclonal Antibody

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

The Lamin A/C(Phospho Ser22) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Lamin A/C protein phosphorylated at Serine 22. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

Lamin A/C is a major component of the nuclear lamina, a network of intermediate filaments that provides structural support to the nucleus. Phosphorylation of Lamin A/C at Serine 22 has been implicated in various cellular processes, including nuclear envelope disassembly during mitosis and regulation of nuclear architecture.

The Lamin A/C(Phospho Ser22) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Lamin A/C in various sample types.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. The Lamin A/C(Phospho Ser22) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the Lamin A/C(Phospho Ser22) Polyclonal Antibody is a valuable tool for researchers studying the role of Lamin A/C phosphorylation in cellular processes. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in the investigation of nuclear architecture and related pathways.