Kv1.3(Phospho Tyr187) Polyclonal Antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and

The Kv1.3(Phospho Tyr187) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Kv1.3 protein phosphorylated at Tyr187. This antibody is produced using state-of-the-art techniques, ensuring high quality and reliability in experimental results.

The Kv1.3 channel plays a crucial role in various physiological processes, including T-cell activation and proliferation. Phosphorylation of Kv1.3 at Tyr187 has been implicated in the regulation of channel activity and cellular signaling pathways. Therefore, the ability to detect and quantify this phosphorylation event is of great importance in understanding the functional implications of Kv1.3 in cellular processes.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Kv1.3 and other related proteins, ensuring accurate and reliable results.

The Kv1.3(Phospho Tyr187) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The antibody is stored at -20°C, ensuring long-term stability and preserving its functionality.

In summary, the Kv1.3(Phospho Tyr187) Polyclonal Antibody is a valuable tool for researchers studying the role of Kv1.3 phosphorylation in cellular processes. Its high specificity, sensitivity, and reliability make it an essential component in the investigation of Kv1.3-mediated signaling pathways and potential therapeutic targets.