KIR6.2(Phospho Thr224) Polyclonal Antibody

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans

The KIR6.2(Phospho Thr224) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of KIR6.2 protein phosphorylated at threonine 224. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for researchers and scientists working in the field of cellular signaling pathways.

The KIR6.2 protein, also known as ATP-sensitive inward rectifier potassium channel 11, plays a crucial role in regulating the activity of potassium channels in various tissues, including the pancreas, heart, and brain. Phosphorylation of KIR6.2 at threonine 224 has been implicated in the modulation of its function and cellular localization.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The KIR6.2(Phospho Thr224) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into existing laboratory protocols. The antibody is compatible with a wide range of applications, including immunohistochemistry, flow cytometry, and ELISA.

With its exceptional performance characteristics and reliable results, the KIR6.2(Phospho Thr224) Polyclonal Antibody is an indispensable tool for researchers investigating the role of KIR6.2 phosphorylation in cellular signaling pathways. Its high specificity and sensitivity make it an invaluable asset in the quest for a deeper understanding of the intricate mechanisms underlying cellular function.