KHDR3 Polyclonal Antibody

The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.,RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.,induction:Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death.,PTM:Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.,Belongs to the KHDRBS family.,Contains 1 KH domain.,subcellular location:Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.,subunit:Self-associates to form homo-oligomers. Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1, RBMX, RBMY1A1 and with p85 subunit of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation.,tissue specificity:Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.,

The KHDR3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of KHDR3 protein expression in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

The KHDR3 Polyclonal Antibody exhibits a high affinity towards the KHDR3 protein, enabling accurate and precise detection even at low concentrations. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its exceptional specificity, this antibody ensures minimal cross-reactivity with other proteins, guaranteeing reliable and accurate results. It offers researchers a valuable tool for studying the role of KHDR3 in various cellular processes and disease mechanisms.

The KHDR3 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows.

Choose the KHDR3 Polyclonal Antibody for its exceptional sensitivity, specificity, and reliability. It is an indispensable tool for researchers seeking to unravel the complexities of KHDR3 protein function and its implications in various biological processes.