KCNQ1 Polyclonal Antibody

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

The KCNQ1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of KCNQ1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human KCNQ1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The KCNQ1 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 75 kDa in Western blot analysis of human heart tissue lysate, which corresponds to the expected molecular weight of KCNQ1 protein. In addition, the antibody shows strong staining of KCNQ1 protein in human heart tissue sections by immunohistochemistry and immunofluorescence.

This antibody is an essential tool for researchers studying the function and regulation of KCNQ1 protein in various physiological and pathological conditions. It can be used to investigate the role of KCNQ1 in cardiac repolarization, long QT syndrome, and other cardiac disorders. Furthermore, it can be used to study the expression and localization of KCNQ1 in various tissues and cell types.

In summary, the KCNQ1 Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. It is an indispensable tool for researchers studying the function and regulation of KCNQ1 protein in health and disease.