KCNN3 (SK3) Polyclonal Antibody

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript v

The KCNN3 (SK3) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of KCNN3 protein expression in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

The KCNN3 protein, also known as the small conductance calcium-activated potassium channel protein 3, plays a crucial role in regulating neuronal excitability and synaptic transmission. Dysregulation of KCNN3 has been implicated in various neurological disorders, making it an important target for research and therapeutic development.

Our KCNN3 (SK3) Polyclonal Antibody has been meticulously developed using state-of-the-art techniques to ensure high specificity and sensitivity. It has been rigorously tested against a wide range of samples, including human, mouse, and rat tissues, to guarantee reliable and reproducible results.

This antibody exhibits exceptional affinity towards the KCNN3 protein, enabling precise and accurate detection even at low expression levels. Its superior performance in IHC, IF, and WB applications allows for detailed visualization and quantification of KCNN3 protein expression in various cellular and tissue contexts.

Furthermore, the KCNN3 (SK3) Polyclonal Antibody demonstrates excellent specificity, showing minimal cross-reactivity with other related proteins. This ensures that the obtained results are highly specific to KCNN3, eliminating any potential confounding factors.

In summary, the KCNN3 (SK3) Polyclonal Antibody is a valuable tool for researchers studying the role of KCNN3 in neurological disorders and synaptic transmission. Its high specificity, sensitivity, and reliability make it an indispensable asset in the field of neuroscience research.