IκB-beta(Phospho Thr19) Polyclonal Antibody

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.

The IκB-beta(Phospho Thr19) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IκB-beta protein phosphorylated at threonine 19. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

IκB-beta is a crucial regulator of the nuclear factor kappa B (NF-κB) signaling pathway, which plays a pivotal role in various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of IκB-beta at threonine 19 is a key post-translational modification that regulates its activity and stability, ultimately influencing NF-κB signaling.

The IκB-beta(Phospho Thr19) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IκB-beta in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. The IκB-beta(Phospho Thr19) Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

In summary, the IκB-beta(Phospho Thr19) Polyclonal Antibody is a valuable tool for studying the phosphorylation status of IκB-beta at threonine 19. Its high specificity, sensitivity, and versatility make it an essential reagent for researchers and clinicians investigating the NF-κB signaling pathway and its implications in various physiological and pathological processes.