IPO9 Polyclonal Antibody

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.,Belongs to the importin beta family.,Contains 1 importin N-terminal domain.,subunit:Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.,

The IPO9 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of IPO9 protein expression in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, ensuring accurate and reproducible results.

The IPO9 Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other proteins to ensure its specificity for IPO9. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior performance characteristics, the IPO9 Polyclonal Antibody is an invaluable tool for researchers studying the role of IPO9 in cellular processes and disease mechanisms. Its high affinity and sensitivity enable the detection of even low levels of IPO9 protein, facilitating accurate quantification and analysis.

The IPO9 Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is stable for long-term storage at -20°C. Each vial contains a sufficient amount of antibody for multiple experiments, ensuring cost-effectiveness and minimizing wastage.

Choose the IPO9 Polyclonal Antibody for its exceptional performance, reliability, and ease of use. It is the ideal choice for researchers seeking accurate and reproducible results in their studies of IPO9 protein expression and function.