IPO5 Polyclonal Antibody

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a me

The IPO5 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of Importin 5 (IPO5) protein. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human IPO5 protein. The IPO5 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The IPO5 protein is a member of the importin family of nuclear transport receptors, which play a crucial role in the transport of proteins and RNA molecules between the cytoplasm and the nucleus. The IPO5 protein specifically recognizes and binds to a subset of nuclear localization signals (NLS) present in cargo proteins, and facilitates their transport into the nucleus. Dysregulation of IPO5 expression has been implicated in various diseases, including cancer and viral infections.

The IPO5 Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of IPO5 protein in various biological processes. It has been shown to specifically detect endogenous IPO5 protein in various human and mouse cell lines, and can be used to monitor changes in IPO5 expression levels under different experimental conditions. The antibody has also been shown to cross-react with IPO5 protein from other species, including rat and zebrafish.

In summary, the IPO5 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of IPO5 protein in various research applications. Its high specificity and sensitivity make it an ideal choice for researchers studying the role of IPO5 in nuclear transport and other biological processes.