IL21R Polyclonal Antibody

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

The IL21R Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of interleukin-21 receptor (IL21R) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human IL21R protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays, including Western blotting, immunohistochemistry, and flow cytometry.

The IL21R Polyclonal Antibody is a valuable tool for researchers studying the role of IL21R in various biological processes, including immune response, inflammation, and cancer. It can be used to detect IL21R expression in different cell types and tissues, as well as to investigate the regulation and signaling pathways of IL21R. This antibody is suitable for use in both basic research and clinical applications, and it has been cited in numerous publications as a reliable and effective reagent for IL21R detection.

In summary, the IL21R Polyclonal Antibody is a high-quality antibody that offers excellent sensitivity and specificity for the detection of IL21R in various biological samples. It is a valuable tool for researchers studying the role of IL21R in different biological processes and can be used in a variety of applications, including Western blotting, immunohistochemistry, and flow cytometry.