IL-12B Polyclonal Antibody

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

The IL-12B Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL-12B protein in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards IL-12B.

IL-12B, also known as interleukin-12 subunit beta, plays a crucial role in the immune response by promoting the differentiation of T cells into Th1 cells and stimulating the production of interferon-gamma. It is involved in various immune-related diseases, including autoimmune disorders and inflammatory conditions.

The IL-12B Polyclonal Antibody is validated for multiple applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). It exhibits excellent performance in terms of sensitivity, specificity, and reproducibility, making it an ideal choice for researchers and clinicians working in the field of immunology and related disciplines.

This antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size and quantity, ensuring cost-effectiveness and minimizing wastage. The IL-12B Polyclonal Antibody is manufactured under strict quality control standards, guaranteeing its reliability and consistency across batches.

In summary, the IL-12B Polyclonal Antibody is a valuable tool for the accurate detection and quantification of IL-12B protein. Its high specificity, sensitivity, and versatility make it an indispensable asset for researchers and clinicians studying immune-related diseases and therapeutic interventions.