Huntingtin(Phospho Ser421) Polyclonal Antibody

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel

The Huntingtin(Phospho Ser421) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Huntingtin protein at serine 421 residue. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Huntingtin protein plays a crucial role in the pathogenesis of Huntington's disease, a neurodegenerative disorder characterized by the progressive loss of motor control, cognitive decline, and psychiatric symptoms. Phosphorylation of Huntingtin at serine 421 has been implicated in the regulation of its function and cellular localization.

This polyclonal antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reproducibility. It exhibits a high affinity and selectivity towards phosphorylated Huntingtin at serine 421, enabling accurate and reliable detection of this post-translational modification.

With its exceptional sensitivity, this antibody allows for the detection of even low levels of phosphorylated Huntingtin, making it an invaluable tool for researchers studying the molecular mechanisms underlying Huntington's disease and related disorders. Its versatility in various applications further enhances its utility in diverse experimental settings.

The Huntingtin(Phospho Ser421) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It has been extensively tested for its stability and consistency, ensuring reliable results with every experiment. Its long shelf life and excellent storage stability make it a cost-effective choice for long-term research projects.

In summary, the Huntingtin(Phospho Ser421) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated Huntingtin protein at serine 421 residue. Its exceptional sensitivity, versatility, and stability make it an indispensable asset for researchers investigating the role of Huntingtin phosphorylation in neurodegenerative diseases.