HLA-DQA1 Polyclonal Antibody

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

The HLA-DQA1 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of HLA-DQA1 protein expression. This antibody is produced through a rigorous purification process, ensuring high purity and quality. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.

The HLA-DQA1 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the HLA-DQA1 protein without cross-reactivity to other HLA-DQ subtypes or unrelated proteins. This specificity enables accurate and reliable detection of HLA-DQA1 expression in various biological samples.

With its high sensitivity, the HLA-DQA1 Polyclonal Antibody allows for the detection of low levels of HLA-DQA1 protein, making it an ideal choice for studies requiring precise quantification. Its robust performance ensures consistent and reproducible results, facilitating reliable data interpretation.

This antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation. It is available in various sizes to accommodate different experimental requirements. Each batch of the HLA-DQA1 Polyclonal Antibody undergoes stringent quality control measures to ensure batch-to-batch consistency and reliability.

In summary, the HLA-DQA1 Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and analysis of HLA-DQA1 protein expression. Its exceptional performance and convenience make it an invaluable asset for researchers in the fields of immunology, genetics, and transplantation.