HLA Class I Polyclonal Antibody

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans

The HLA Class I Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of human leukocyte antigen (HLA) Class I molecules. This antibody is produced through a rigorous process of immunization with purified HLA Class I proteins, ensuring its high affinity and specificity towards these molecules.

With its exceptional sensitivity, this polyclonal antibody enables accurate identification and quantification of HLA Class I molecules in various biological samples. It is suitable for use in a wide range of applications, including flow cytometry, immunohistochemistry, and Western blotting.

The HLA Class I Polyclonal Antibody exhibits excellent performance in both research and clinical settings. Its robust and consistent results make it an indispensable tool for studying HLA Class I expression patterns, understanding immune responses, and investigating the role of HLA Class I molecules in various diseases.

This antibody is manufactured under strict quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows.

Choose the HLA Class I Polyclonal Antibody for its exceptional specificity, sensitivity, and reliability. Experience accurate and reproducible results in your research or clinical applications with this high-quality antibody.