HJURP Polyclonal Antibody

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.,sequence Translated as Arg.,subcellular location:Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.,subunit:Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.,tissue specificity:According to PubMed:17256767 highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411 highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.,

The HJURP Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect the HJURP protein in various biological samples. This antibody has been extensively validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The HJURP protein is a key regulator of chromatin assembly during DNA replication and cell division, and its dysregulation has been implicated in various human diseases, including cancer. The HJURP Polyclonal Antibody has been developed to enable researchers to study the expression and function of this important protein in normal and diseased tissues.

This antibody has been produced using high-quality materials and rigorous quality control procedures to ensure its specificity and sensitivity. It has been validated using a range of techniques, including siRNA knockdown and overexpression studies, to confirm its specificity for the HJURP protein.

The HJURP Polyclonal Antibody is supplied in a convenient format, with a range of sizes available to suit different experimental needs. It is also available with a range of conjugates, including HRP, FITC, and biotin, to enable detection using a variety of detection methods.

Overall, the HJURP Polyclonal Antibody is a reliable and effective tool for studying the expression and function of the HJURP protein in a wide range of biological samples. Its high specificity and sensitivity make it an ideal choice for researchers working in the fields of cancer biology, cell biology, and molecular biology.