Histone H4(Phospho Ser1) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.

The Histone H4(Phospho Ser1) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Serine 1 residue on Histone H4 protein. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H4 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Phosphorylation of Serine 1 on Histone H4 has been implicated in various cellular processes, including transcriptional activation, DNA repair, and cell cycle progression. Therefore, the detection and quantification of this phosphorylation event are of great importance in understanding the underlying molecular mechanisms.

The Histone H4(Phospho Ser1) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Serine 1 on Histone H4. It has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is produced using high-quality materials and undergoes rigorous quality control procedures to ensure consistent performance and reliability. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

In summary, the Histone H4(Phospho Ser1) Polyclonal Antibody is a valuable tool for researchers studying epigenetics, chromatin biology, and cellular signaling pathways. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in the investigation of histone modifications and their functional implications.