Histone H3.3(Phospho Ser31) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.

The Histone H3.3(Phospho Ser31) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Histone H3.3 protein phosphorylated at Serine 31. This antibody is produced using high-quality materials and advanced techniques to ensure optimal performance and reliability.

Histone H3.3 is a variant of the core histone H3 protein that plays a crucial role in chromatin remodeling and gene expression regulation. Phosphorylation of Histone H3.3 at Serine 31 has been implicated in various cellular processes, including DNA repair, cell cycle progression, and transcriptional activation.

The Histone H3.3(Phospho Ser31) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other histone H3 variants and phosphorylation sites, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended to store the antibody at -20°C for long-term use to maintain its stability and activity.

In summary, the Histone H3.3(Phospho Ser31) Polyclonal Antibody is a valuable tool for researchers studying the role of Histone H3.3 phosphorylation in various biological processes. Its high specificity, sensitivity, and reliability make it an essential component of any study involving Histone H3.3 protein analysis.