Histone H3(Phospho Thr32) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3(Phospho Thr32) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Histone H3 at Thr32 residue. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H3 is a crucial protein involved in chromatin structure and gene regulation. Phosphorylation of Histone H3 at Thr32 has been implicated in various cellular processes, including DNA damage response, cell cycle progression, and transcriptional regulation. Therefore, the detection and quantification of phosphorylated Histone H3 at Thr32 is of great importance in understanding these biological processes.

The Histone H3(Phospho Thr32) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

With its high-quality formulation and optimized protocols, this antibody offers researchers a valuable tool for studying the role of phosphorylated Histone H3 at Thr32 in cellular processes and disease mechanisms. Its versatility and reliability make it an indispensable asset for both basic research and clinical applications.

Order the Histone H3(Phospho Thr32) Polyclonal Antibody today and unlock new insights into the intricate world of chromatin biology and epigenetics.