Histone H2B Polyclonal Antibody

H2BFS is a Pseudogene. Histone H2B type 1-H is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Diseases associated with H2BFS include endometrial stromal sarcoma. Among its related pathways are Packaging Of Telomere Ends. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H2BA is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from HIST1H2BA contain a palindromic termination element.

The Histone H2B Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H2B protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards histone H2B.

Histone H2B is a crucial component of the nucleosome, playing a vital role in chromatin structure and gene regulation. This antibody recognizes both the unmodified and modified forms of histone H2B, making it an ideal choice for studying epigenetic modifications and their impact on gene expression.

The Histone H2B Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It provides reliable and reproducible results, enabling accurate quantification and localization of histone H2B in various cell types and tissues.

With its high sensitivity and specificity, this antibody is an invaluable tool for researchers and scientists working in the fields of chromatin biology, epigenetics, and gene regulation. Its superior performance and versatility make it an essential component of any laboratory studying histone H2B and its role in cellular processes.

Order the Histone H2B Polyclonal Antibody today and unlock new insights into the intricate mechanisms of chromatin structure and gene regulation.