Histone H2A.X(Phospho Thr120) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

The Histone H2A.X(Phospho Thr120) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Histone H2A.X at Thr120 residue. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

Histone H2A.X is a variant of the histone H2A family and plays a crucial role in DNA damage response and repair. Phosphorylation of Histone H2A.X at Thr120 is an important post-translational modification that occurs in response to DNA double-strand breaks. This modification serves as a marker for DNA damage and is involved in the recruitment of repair proteins to the damaged sites.

The Histone H2A.X(Phospho Thr120) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Histone H2A.X and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for additional preparation steps. The recommended working dilution range and optimal conditions for each application are provided in the product manual, ensuring successful experiments.

With its high specificity, sensitivity, and reliability, the Histone H2A.X(Phospho Thr120) Polyclonal Antibody is an essential tool for researchers studying DNA damage response and repair pathways. Its superior performance and ease of use make it an ideal choice for a wide range of applications in molecular biology and biomedical research.