Histone H2A.X (Acetyl Lys5) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

The Histone H2A.X (Acetyl Lys5) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Histone H2A.X protein acetylated at Lysine 5. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

Histone H2A.X is a variant of the histone H2A family and plays a crucial role in DNA damage response and repair. Acetylation of Lysine 5 on Histone H2A.X has been implicated in various cellular processes, including chromatin remodeling, transcriptional regulation, and DNA repair. Therefore, the detection and quantification of acetylated Histone H2A.X are of great importance in understanding these biological processes.

The Histone H2A.X (Acetyl Lys5) Polyclonal Antibody exhibits excellent performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in multiple species, including human, mouse, and rat, ensuring its versatility and applicability in diverse research settings.

With its high specificity and sensitivity, this antibody enables accurate and reliable detection of acetylated Histone H2A.X, facilitating the investigation of its role in DNA damage response, chromatin remodeling, and other cellular processes. Researchers can confidently rely on this antibody to obtain robust and reproducible results in their studies.

In summary, the Histone H2A.X (Acetyl Lys5) Polyclonal Antibody is a valuable tool for researchers interested in studying the acetylation of Histone H2A.X and its implications in various biological processes. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory focused on chromatin biology, DNA repair, and epigenetics research.