Histone H1(Phospho Thr17) Polyclonal Antibody

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

The Histone H1(Phospho Thr17) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of phosphorylated Histone H1 at Thr17 residue. This antibody has been rigorously tested and validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Histone H1 is a key component of chromatin structure and plays a crucial role in the regulation of gene expression and chromatin condensation. Phosphorylation of Histone H1 at Thr17 has been implicated in various cellular processes, including cell cycle progression, DNA repair, and apoptosis. Therefore, the ability to specifically detect and quantify phosphorylated Histone H1 at Thr17 is of great importance in understanding the underlying mechanisms of these processes.

The Histone H1(Phospho Thr17) Polyclonal Antibody has been developed using high-quality immunogens and state-of-the-art techniques to ensure its specificity and sensitivity. It has been extensively characterized and validated using both in vitro and in vivo models, demonstrating its reliability and reproducibility.

This antibody exhibits excellent performance in Western blotting, allowing for the detection of phosphorylated Histone H1 at Thr17 in a variety of sample types, including cell lysates and tissue extracts. It shows a strong signal with minimal background noise, enabling accurate and reliable quantification of phosphorylated Histone H1 levels.

In addition to Western blotting, the Histone H1(Phospho Thr17) Polyclonal Antibody can also be used in immunohistochemistry and immunofluorescence applications. It provides clear and specific staining of phosphorylated Histone H1 in tissue sections and cultured cells, allowing for the visualization and localization of this important post-translational modification.

Overall, the Histone H1(Phospho Thr17) Polyclonal Antibody is a valuable tool for researchers studying the role of phosphorylated Histone H1 in various cellular processes. Its high specificity, sensitivity, and reliability make it an ideal choice for a wide range of applications, providing valuable insights into the complex mechanisms of gene regulation and chromatin dynamics.