Histamine H1 Receptor(Phospho Ser398) Polyclonal Antibody

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

The Histamine H1 Receptor (Phospho Ser398) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of the phosphorylated form of the Histamine H1 receptor at serine 398. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Histamine H1 receptor plays a crucial role in mediating the effects of histamine, a key neurotransmitter involved in various physiological and pathological processes. Phosphorylation of the receptor at serine 398 has been shown to modulate its activity and downstream signaling pathways. Therefore, the ability to specifically detect and quantify the phosphorylated form of the receptor is of great importance in understanding its functional regulation and potential therapeutic implications.

This polyclonal antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reliability. It exhibits high affinity and specificity towards the phosphorylated form of the Histamine H1 receptor at serine 398, while showing minimal cross-reactivity with other related proteins. This antibody has been extensively tested and validated using a variety of experimental models and sample types, ensuring accurate and reproducible results.

The Histamine H1 Receptor (Phospho Ser398) Polyclonal Antibody is supplied as a ready-to-use solution, allowing for convenient and efficient use in various experimental settings. It is provided in a liquid format, ensuring ease of handling and minimizing the risk of sample loss or contamination. The antibody is available in different sizes to accommodate the specific needs of researchers and can be stored at recommended temperatures for long-term use.

In summary, the Histamine H1 Receptor (Phospho Ser398) Polyclonal Antibody is a reliable and highly specific tool for the detection and quantification of the phosphorylated form of the Histamine H1 receptor at serine 398. Its exceptional performance and versatility make it an invaluable asset for researchers studying the functional regulation and therapeutic potential of this important receptor.