HIPK3 Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for Catalytic activity.,PTM:May be sumoylated.,Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.,

The HIPK3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of HIPK3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human HIPK3 protein. The HIPK3 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in Western blotting, immunohistochemistry, and immunofluorescence assays. It recognizes endogenous levels of HIPK3 protein in various cell lines and tissues. This antibody is an essential tool for researchers studying the function and regulation of HIPK3 protein in various biological processes, including cell proliferation, apoptosis, and DNA damage response. The HIPK3 Polyclonal Antibody is supplied as a purified IgG fraction, and it is suitable for use in various applications, including ELISA, immunoprecipitation, and flow cytometry. With its high specificity and sensitivity, the HIPK3 Polyclonal Antibody is an ideal choice for researchers seeking a reliable and accurate tool for the detection of HIPK3 protein in their experiments.