HIF-1 beta Polyclonal Antibody

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.

The HIF-1 beta Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of HIF-1 beta protein in various biological samples. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

HIF-1 beta, also known as ARNT (Aryl hydrocarbon receptor nuclear translocator), is a critical transcription factor involved in the regulation of cellular responses to hypoxia. It plays a crucial role in the activation of genes that are essential for adaptation to low oxygen conditions. Dysregulation of HIF-1 beta has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.

The HIF-1 beta Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of HIF-1 beta protein in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The HIF-1 beta Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the HIF-1 beta Polyclonal Antibody is a valuable tool for researchers studying the role of HIF-1 beta in various biological processes and diseases. Its high specificity, sensitivity, and reliability make it an essential component of any laboratory involved in HIF-1 beta research.