HCAR2 Polyclonal Antibody

developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase.,Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.,miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.,

The HCAR2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of HCAR2 protein in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The HCAR2 Polyclonal Antibody is ideal for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is designed to recognize the HCAR2 protein, which is a G protein-coupled receptor that is involved in various physiological processes, including glucose metabolism, inflammation, and immune response. The HCAR2 Polyclonal Antibody has been extensively tested and validated for its specificity and sensitivity, ensuring accurate and reliable results in various experimental settings.

The HCAR2 Polyclonal Antibody is supplied in a convenient format, making it easy to use in a variety of applications. It is available in different sizes to suit different experimental needs. This antibody is manufactured to the highest standards of quality and purity, ensuring consistent and reliable performance.

In summary, the HCAR2 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of HCAR2 protein in various biological samples. It is a valuable tool for researchers studying the physiological functions of HCAR2 and its role in various diseases.