GRK 2(Phospho Ser29) Polyclonal Antibody

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

The GRK 2(Phospho Ser29) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of GRK 2 protein phosphorylated at Serine 29. This antibody is produced using state-of-the-art techniques, ensuring high purity and quality.

GRK 2, also known as G protein-coupled receptor kinase 2, plays a crucial role in regulating the desensitization and internalization of G protein-coupled receptors (GPCRs). Phosphorylation of GRK 2 at Serine 29 has been implicated in various cellular processes, including signal transduction, receptor trafficking, and cellular homeostasis.

The GRK 2(Phospho Ser29) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of GRK 2 at Serine 29, making it an ideal tool for studying the functional significance of this post-translational modification. It has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its performance. The GRK 2(Phospho Ser29) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

In summary, the GRK 2(Phospho Ser29) Polyclonal Antibody is a reliable and versatile tool for investigating the phosphorylation status of GRK 2 at Serine 29. Its high specificity, sensitivity, and ease of use make it an essential reagent for researchers studying GPCR signaling pathways and related cellular processes.