GluR-2(Phospho-Tyr876) Polyclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco

The GluR-2(Phospho-Tyr876) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of GluR-2 protein phosphorylated at tyrosine 876. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The GluR-2 protein, a member of the ionotropic glutamate receptor family, plays a crucial role in synaptic transmission and plasticity in the central nervous system. Phosphorylation of GluR-2 at tyrosine 876 has been implicated in various physiological and pathological processes, including synaptic plasticity, learning, memory, and neurodegenerative diseases.

This polyclonal antibody is rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The GluR-2(Phospho-Tyr876) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into various experimental protocols. The antibody is compatible with a wide range of applications, including immunohistochemistry, immunocytochemistry, and flow cytometry.

Researchers and scientists can confidently rely on the GluR-2(Phospho-Tyr876) Polyclonal Antibody to facilitate their investigations into the role and regulation of GluR-2 phosphorylation in neuronal function and dysfunction. Its exceptional quality and performance make it an indispensable tool for studying the intricate mechanisms underlying synaptic plasticity and neurological disorders.