FRS2(Phospho Tyr436) Polyclonal Antibody

Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence Translated as stop.,Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

The FRS2(Phospho Tyr436) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of FRS2 protein phosphorylated at tyrosine 436. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The FRS2 protein plays a crucial role in the signaling pathways of growth factors and cytokines, particularly in the activation of the MAPK/ERK and PI3K/AKT pathways. Phosphorylation of FRS2 at tyrosine 436 is a key event in the activation of downstream signaling cascades, making it an important target for research in the field of cell signaling and cancer biology.

This polyclonal antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reproducibility. It exhibits high affinity and specificity towards the phosphorylated form of FRS2 at tyrosine 436, enabling accurate and reliable detection of this critical post-translational modification.

The FRS2(Phospho Tyr436) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It has been extensively tested and validated in various cell lines and tissues, ensuring its suitability for a wide range of experimental settings.

Researchers can confidently utilize this antibody to investigate the role of FRS2 phosphorylation in various cellular processes, such as cell proliferation, differentiation, and survival. Its application in both basic research and drug development makes it an invaluable tool for scientists working in the fields of cell biology, molecular biology, and cancer research.

In summary, the FRS2(Phospho Tyr436) Polyclonal Antibody offers exceptional sensitivity, specificity, and reproducibility for the detection and quantification of FRS2 protein phosphorylated at tyrosine 436. Its high-quality formulation and extensive validation make it an ideal choice for researchers seeking to unravel the intricate signaling pathways regulated by FRS2 and its potential implications in disease progression.