FOG1 Polyclonal Antibody

The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.,Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the FOG (Friend of GATA) family.,Contains 4 C2H2-type zinc fingers.,Contains 5 C2HC-type zinc fingers.,subunit:Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.,tissue specificity:Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.,

The FoxO4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of FoxO4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human FoxO4 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The FoxO4 protein is a member of the Forkhead box O (FoxO) family of transcription factors, which play important roles in regulating cellular processes such as apoptosis, cell cycle progression, and oxidative stress response. FoxO4 has been implicated in a variety of physiological and pathological processes, including aging, cancer, and neurodegenerative diseases. The FoxO4 Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of FoxO4 protein in these and other contexts.

This antibody has been validated for use in human, mouse, and rat samples, and has been shown to exhibit high specificity and sensitivity in detecting FoxO4 protein. It is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. The FoxO4 Polyclonal Antibody is a reliable and effective tool for researchers investigating the role of FoxO4 protein in various biological processes.