Flt3(Phospho Tyr599) Polyclonal Antibody

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

The Flt3(Phospho Tyr599) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Flt3 protein phosphorylated at tyrosine 599 residue. This antibody is produced through a rigorous process of immunization and purification, ensuring high affinity and specificity towards the target protein.

Flt3, also known as Fms-like tyrosine kinase 3, is a receptor tyrosine kinase that plays a crucial role in hematopoiesis and immune cell development. Phosphorylation of tyrosine 599 residue is known to regulate the activation and downstream signaling of Flt3, making it an important site for investigation in various cellular processes.

The Flt3(Phospho Tyr599) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been validated for use in both human and animal samples, ensuring its versatility and applicability across different research fields.

With its high sensitivity and specificity, this antibody enables researchers to accurately analyze the phosphorylation status of Flt3 at tyrosine 599 residue, providing valuable insights into the molecular mechanisms underlying Flt3 signaling pathways. Its reliable performance and reproducibility make it an indispensable tool for scientists studying hematopoiesis, immune cell development, and related diseases.

The Flt3(Phospho Tyr599) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows. It is provided in a liquid formulation, ensuring stability and ease of handling. Each batch of antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the Flt3(Phospho Tyr599) Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of Flt3 protein phosphorylated at tyrosine 599 residue. Its exceptional performance, versatility, and reliability make it an essential component for researchers investigating Flt3 signaling pathways and related cellular processes.