ER alpha(Phospho Ser305) Polyclonal Antibody

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

The ER alpha(Phospho Ser305) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Ser305 of the estrogen receptor alpha (ER alpha) protein. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated Ser305 residue of ER alpha.

The ER alpha protein plays a crucial role in mediating estrogen signaling and is involved in various physiological processes, including cell proliferation, differentiation, and development. Phosphorylation of specific residues within ER alpha can modulate its activity and influence downstream signaling pathways.

The ER alpha(Phospho Ser305) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated ER alpha and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use in various applications, including research studies, drug development, and clinical diagnostics. It is compatible with multiple detection methods, such as chemiluminescence, fluorescence, and colorimetric assays, providing flexibility and convenience for different experimental setups.

With its exceptional performance and reliability, the ER alpha(Phospho Ser305) Polyclonal Antibody is an indispensable tool for researchers and scientists working in the field of estrogen signaling and related areas. Its high specificity and sensitivity make it an ideal choice for investigating the role of phosphorylation in ER alpha function and its implications in various physiological and pathological conditions.