ERK 8(Phospho Thr175/Y177) Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation.,The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1.,In vitro, phosphorylates MBP.,PTM:Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.,PTM:Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase.,Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,Contains 1 protein kinase domain.,subunit:Interacts with CSK/c-Src, ABL1, RET and TGFB1I1.,tissue specificity:Widely expressed with a maximal expression in lung and kidney.,

The ERK 8(Phospho Thr175/Y177) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated ERK 8 protein. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The ERK 8(Phospho Thr175/Y177) Polyclonal Antibody is raised in rabbits and purified using a combination of affinity chromatography and protein A/G purification methods. This rigorous purification process guarantees a high level of purity and specificity, minimizing the risk of cross-reactivity with non-target proteins.

This antibody has been validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated ERK 8 protein in various biological samples.

The ERK 8(Phospho Thr175/Y177) Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a 1 mg/mL concentration, ensuring sufficient antibody for multiple experiments. The antibody is also available in different sizes to accommodate various experimental needs.

With its exceptional performance and reliability, the ERK 8(Phospho Thr175/Y177) Polyclonal Antibody is an indispensable tool for researchers studying ERK 8 signaling pathways and its role in various biological processes. Its high specificity and sensitivity make it an ideal choice for accurate and precise detection of phosphorylated ERK 8 protein, facilitating further understanding of its function and potential therapeutic applications.