ErbB-3(Phospho Tyr1328) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

The ErbB-3(Phospho Tyr1328) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of ErbB-3 protein phosphorylated at Tyr1328. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The ErbB-3 receptor tyrosine kinase plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of Tyr1328 is a key event in the activation of ErbB-3 signaling pathway, which is implicated in various physiological and pathological processes, including cancer development and progression.

This polyclonal antibody has been developed using state-of-the-art techniques and high-quality materials to ensure exceptional performance and reliability. It exhibits high specificity towards the phosphorylated form of ErbB-3 at Tyr1328, with minimal cross-reactivity to non-phosphorylated ErbB-3 or other related proteins.

The ErbB-3(Phospho Tyr1328) Polyclonal Antibody offers superior sensitivity, enabling the detection of low levels of phosphorylated ErbB-3 in complex biological samples. It provides robust and reproducible results, making it an ideal choice for both basic research and clinical applications.

With its excellent performance characteristics, this antibody is an invaluable tool for studying the role of ErbB-3 phosphorylation in various cellular processes and disease states. Its versatility and reliability make it an essential component of any research or diagnostic laboratory focused on ErbB-3 signaling.

Order the ErbB-3(Phospho Tyr1328) Polyclonal Antibody today and unlock new insights into the complex mechanisms underlying ErbB-3 signaling and its implications in disease.