ErbB-3(Phospho Tyr1197) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

The ErbB-3(Phospho Tyr1197) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of ErbB-3 protein phosphorylated at tyrosine 1197. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The ErbB-3 receptor is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of tyrosine 1197 is a key event in the activation of ErbB-3 signaling pathway, which is implicated in various physiological and pathological processes, including cancer.

This polyclonal antibody has been developed using high-quality immunogens and advanced immunization techniques, ensuring its exceptional specificity and sensitivity. It exhibits minimal cross-reactivity with other proteins, allowing for accurate and reliable detection of ErbB-3 phosphorylated at tyrosine 1197.

The ErbB-3(Phospho Tyr1197) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into various experimental protocols. The antibody has been extensively tested and validated in multiple cell lines and tissues, ensuring its consistent performance across different sample types.

With its exceptional specificity, sensitivity, and versatility, the ErbB-3(Phospho Tyr1197) Polyclonal Antibody is an indispensable tool for researchers studying ErbB-3 signaling pathway and its involvement in various biological processes and diseases.