EDEM1 Polyclonal Antibody

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity.,Belongs to the glycosyl hydrolase 47 family.,subunit:Interacts with DERL2 and DERL3.,

The EDEM1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of EDEM1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

EDEM1, also known as ER degradation-enhancing alpha-mannosidase-like protein 1, is a crucial component of the endoplasmic reticulum-associated degradation (ERAD) pathway. It plays a vital role in recognizing and targeting misfolded proteins for degradation, thereby maintaining cellular homeostasis. Dysregulation of EDEM1 has been implicated in various pathological conditions, including neurodegenerative diseases and cancer.

The EDEM1 Polyclonal Antibody exhibits exceptional specificity, enabling accurate detection of EDEM1 protein expression in a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids. It has been extensively validated for use in various applications, such as Western blotting, immunohistochemistry, and immunofluorescence.

This antibody offers numerous advantages, including high sensitivity, low background noise, and excellent reproducibility. It is manufactured under stringent quality control measures to ensure batch-to-batch consistency and optimal performance. Additionally, it is provided in a convenient liquid format, allowing for easy handling and storage.

In summary, the EDEM1 Polyclonal Antibody is a valuable research tool for investigating the role of EDEM1 in protein quality control and its implications in various disease states. Its exceptional specificity and reliability make it an indispensable asset for researchers in the fields of molecular biology, biochemistry, and biomedical sciences.