EAAT2 Polyclonal Antibody

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

The EAAT2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the excitatory amino acid transporter 2 (EAAT2) protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The EAAT2 protein plays a crucial role in the regulation of glutamate, the major excitatory neurotransmitter in the central nervous system. Dysregulation of EAAT2 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). Therefore, accurate measurement of EAAT2 protein levels is essential for understanding the underlying mechanisms of these diseases and developing effective therapeutic strategies.

The EAAT2 Polyclonal Antibody exhibits high affinity and specificity towards the EAAT2 protein, enabling precise and accurate detection in various sample types, including tissue lysates and cell extracts. It has been extensively validated in multiple experimental settings, demonstrating excellent performance in Western blotting, immunohistochemistry, and immunofluorescence applications.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone reconstitution steps. The EAAT2 Polyclonal Antibody is available in different sizes to accommodate various experimental needs.

In summary, the EAAT2 Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of EAAT2 protein. Its high specificity, sensitivity, and ease of use make it an ideal choice for researchers and clinicians studying the role of EAAT2 in neurological disorders.