The DNA Ligase IV(Phospho Thr650) Polyclonal Antibody

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

The DNA Ligase IV(Phospho Thr650) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of DNA Ligase IV protein phosphorylated at threonine 650. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

DNA Ligase IV is a crucial enzyme involved in the repair of DNA double-strand breaks. Phosphorylation of threonine 650 has been shown to regulate the activity and function of DNA Ligase IV, making it an important target for research in DNA repair mechanisms and related fields.

This polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of DNA Ligase IV(Phospho Thr650) in various biological samples.

With its high-quality formulation and reliable performance, the DNA Ligase IV(Phospho Thr650) Polyclonal Antibody is an indispensable tool for researchers and scientists working in the fields of DNA repair, genomics, and molecular biology. Its application in various experimental techniques allows for a comprehensive understanding of the role and regulation of DNA Ligase IV in cellular processes.

Order this DNA Ligase IV(Phospho Thr650) Polyclonal Antibody today and enhance your research capabilities with a reliable and specific tool for the detection and analysis of phosphorylated DNA Ligase IV.