DMD Polyclonal Antibody

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as enc

The DMD Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of dystrophin, a key protein involved in maintaining the structural integrity of muscle fibers. This antibody is produced through a rigorous process, ensuring its exceptional quality and performance.

With its polyclonal nature, this antibody exhibits a broad reactivity, allowing for the detection of dystrophin in various species and tissues. Its high affinity and sensitivity enable accurate and precise results, making it an indispensable tool for researchers and clinicians alike.

The DMD Polyclonal Antibody is validated for multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility and compatibility with different experimental techniques make it an ideal choice for a wide range of research studies and diagnostic applications.

This antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. Its long shelf life and stability guarantee consistent and reliable results, even after prolonged storage.

Choose the DMD Polyclonal Antibody for its exceptional quality, reliability, and versatility. With its outstanding performance and broad reactivity, it is an essential tool for investigating dystrophin-related disorders and advancing scientific knowledge in the field of muscle biology.