DFFB Polyclonal Antibody

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.

The DFFB Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of DFFB protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human DFFB protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The DFFB Polyclonal Antibody is a valuable tool for researchers studying apoptosis and cell death pathways, as well as those investigating the role of DFFB in various diseases. With its high quality and reliability, this antibody is an essential component of any research project requiring the detection of DFFB protein.

The DFFB Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of DNA fragmentation factor subunit beta (DFFB) in various biological samples. This antibody is produced through a rigorous process, ensuring its exceptional quality and performance.

With its exceptional specificity, the DFFB Polyclonal Antibody exhibits minimal cross-reactivity with other proteins, enabling accurate and precise results. It has been extensively validated in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The DFFB Polyclonal Antibody offers outstanding sensitivity, allowing for the detection of even low levels of DFFB in samples. Its high affinity ensures reliable and reproducible results, making it an ideal choice for researchers and scientists working in the field of DNA fragmentation analysis.

This antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparations. It is available in various sizes to accommodate different experimental requirements.

The DFFB Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reliability. It is provided with comprehensive technical support, including detailed protocols and troubleshooting guidelines, to facilitate successful experiments.

In summary, the DFFB Polyclonal Antibody is a superior tool for the detection and analysis of DFFB in various biological samples. Its exceptional specificity, sensitivity, and reliability make it an indispensable asset for researchers in the field.