Cystatin B Polyclonal Antibody

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG rep

The Cystatin B Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cystatin B protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Cystatin B protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Cystatin B protein, making it an ideal tool for various research applications.

The Cystatin B Polyclonal Antibody has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been shown to detect endogenous levels of Cystatin B protein in various human tissues and cell lines. This antibody is also suitable for use in other applications such as ELISA, flow cytometry, and immunoprecipitation.

The Cystatin B Polyclonal Antibody is supplied as a liquid solution in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research projects. This antibody is manufactured under strict quality control standards to ensure consistent performance and reproducibility.

In summary, the Cystatin B Polyclonal Antibody is a reliable and versatile tool for the detection of Cystatin B protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying the role of Cystatin B in various physiological and pathological processes.