Cyclin D1(Phospho Thr286) Polyclonal Antibody

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Introducing the Cyclin D1(Phospho Thr286) Polyclonal Antibody, a highly advanced and meticulously developed scientific tool designed to facilitate accurate and reliable detection of Cyclin D1 protein phosphorylated at threonine 286. This cutting-edge antibody is specifically engineered to target and bind to the phosphorylated form of Cyclin D1, enabling researchers to gain valuable insights into the intricate mechanisms underlying cell cycle regulation.

Crafted with utmost precision and utilizing state-of-the-art technology, this polyclonal antibody exhibits exceptional specificity and sensitivity, ensuring optimal performance in a wide range of applications, including immunohistochemistry, western blotting, and immunofluorescence. Its robust design allows for the detection of Cyclin D1(Phospho Thr286) in various sample types, including tissue lysates and cell extracts, enabling comprehensive analysis of protein expression and localization.

The Cyclin D1(Phospho Thr286) Polyclonal Antibody is meticulously validated through rigorous quality control measures, guaranteeing consistent and reproducible results. Its exceptional affinity for the phosphorylated form of Cyclin D1 ensures minimal cross-reactivity with non-phosphorylated forms, thereby enhancing the accuracy and reliability of experimental outcomes.

With its user-friendly application protocol and compatibility with various experimental techniques, this antibody empowers researchers to delve deeper into the intricate molecular pathways associated with cell cycle progression and proliferation. By providing a reliable tool for the detection of Cyclin D1(Phospho Thr286), this antibody opens up new avenues for scientific exploration and contributes to the advancement of biomedical research.

In summary, the Cyclin D1(Phospho Thr286) Polyclonal Antibody represents a breakthrough in the field of molecular biology, offering researchers an invaluable tool to unravel the complexities of cell cycle regulation. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset for scientists seeking to elucidate the role of Cyclin D1 phosphorylation in various physiological and pathological processes.