CUL5 Polyclonal Antibody

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.,pathway:Protein modification; protein ubiquitination.,PTM:Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.,Belongs to the cullin family.,subunit:Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.,

The CUL5 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cullin 5 (CUL5) protein in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The CUL5 Polyclonal Antibody is a valuable tool for researchers studying the role of CUL5 in various cellular processes, including protein degradation, cell cycle regulation, and DNA damage response. This antibody has been extensively tested and validated for its specificity and sensitivity, ensuring accurate and reliable results in all applications.

The CUL5 Polyclonal Antibody is supplied in a convenient format, with ample quantities available for multiple experiments. This antibody is also compatible with a range of secondary antibodies, allowing for easy detection and analysis of CUL5 protein in various sample types.

Overall, the CUL5 Polyclonal Antibody is a high-quality and reliable tool for researchers studying the function and regulation of CUL5 protein in various biological systems. Its specificity, sensitivity, and versatility make it an essential component of any research program focused on understanding the complex mechanisms of cellular processes.