CREB-2(Phospho Ser245) Polyclonal Antibody

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

The CREB-2(Phospho Ser245) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated CREB-2 at Ser245 residue. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target antigen.

The phosphorylation of CREB-2 at Ser245 plays a crucial role in various cellular processes, including gene expression regulation, neuronal plasticity, and memory formation. By targeting this specific phosphorylation site, the CREB-2(Phospho Ser245) Polyclonal Antibody enables researchers to investigate the intricate signaling pathways involved in these processes.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, allowing for accurate and reliable detection of phosphorylated CREB-2 in complex biological samples.

The CREB-2(Phospho Ser245) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its exceptional performance and versatility, the CREB-2(Phospho Ser245) Polyclonal Antibody is an indispensable tool for researchers studying the intricate mechanisms underlying cellular processes such as gene expression regulation, neuronal plasticity, and memory formation.