COX4 Polyclonal Antibody

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes

The COX4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of COX4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human COX4 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards COX4 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The COX4 Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested to ensure consistent and reliable results. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage and to avoid repeated freeze-thaw cycles.

Overall, the COX4 Polyclonal Antibody is a valuable tool for researchers studying mitochondrial function and metabolism, as well as those investigating diseases related to mitochondrial dysfunction. Its high specificity and sensitivity make it an excellent choice for detecting COX4 protein in various biological samples.