Connexin-26 Polyclonal Antibody

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

The Connexin-26 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Connexin-26 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity towards Connexin-26.

Connexin-26, also known as GJB2, is a member of the connexin family of proteins, which play a crucial role in intercellular communication through gap junction channels. Connexin-26 is predominantly expressed in the inner ear, where it is involved in the maintenance of normal auditory function. Mutations in the GJB2 gene have been associated with various hearing impairments, making the detection and analysis of Connexin-26 protein expression of great importance in both research and clinical settings.

The Connexin-26 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other connexin family members, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The Connexin-26 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent performance and reproducibility.

In summary, the Connexin-26 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Connexin-26 protein expression. Its advanced immunization techniques, extensive validation, and convenient formulation make it an ideal choice for researchers and clinicians studying the role of Connexin-26 in auditory function and associated disorders.