CLD14 Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several

The CLD14 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of the human CLD14 protein. The resulting polyclonal antibody has been extensively validated for its specificity and sensitivity in detecting CLD14 protein expression in various tissues and cell types.

The CLD14 Polyclonal Antibody is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to detect endogenous levels of CLD14 protein in human, mouse, and rat tissues, making it a versatile tool for researchers studying the function and expression of this protein.

This antibody is supplied as a purified IgG fraction, and has been tested and validated for use in a variety of experimental conditions. It is recommended for use at a dilution of 1:1000 for Western blotting, and 1:200 for immunohistochemistry and immunofluorescence.

Overall, the CLD14 Polyclonal Antibody is a reliable and effective tool for researchers studying the CLD14 protein and its role in various biological processes. Its high specificity and sensitivity make it a valuable addition to any research laboratory.