CLAP2 Polyclonal Antibody

alternative products:Additional isoforms exist,Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.,PTM:Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella. Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the CLASP family.,Contains 5 HEAT repeats.,subcellular location:Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.,subunit:Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2.,tissue specificity:Brain-specific.,

The CLAP2 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The CLAP2 Polyclonal Antibody is ideal for use in immunohistochemistry, western blotting, and other applications where high specificity and sensitivity are required.

This antibody is designed to recognize and bind to the CLAP2 protein, which is a key regulator of cell proliferation and differentiation. The CLAP2 Polyclonal Antibody has been extensively tested and validated for its ability to detect CLAP2 in a variety of tissues and cell types. It is highly specific and does not cross-react with other proteins, ensuring accurate and reliable results.

The CLAP2 Polyclonal Antibody is supplied in a convenient format that is easy to use and store. It is available in a range of sizes to suit different research needs. This antibody is manufactured to the highest standards of quality and purity, ensuring consistent and reliable results.

In summary, the CLAP2 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for use in a range of research applications. Its high specificity and sensitivity make it an essential tool for researchers studying cell proliferation and differentiation. With its convenient format and reliable performance, the CLAP2 Polyclonal Antibody is an excellent choice for any research laboratory.