CHOP(Phospho Ser30) Polyclonal Antibody

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

The CHOP(Phospho Ser30) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of CHOP protein phosphorylated at Serine 30. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

The CHOP protein, also known as C/EBP homologous protein, plays a crucial role in cellular stress response and apoptosis. Phosphorylation of CHOP at Serine 30 has been implicated in various cellular processes, including endoplasmic reticulum stress-induced apoptosis and regulation of gene expression.

This polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated CHOP protein in various biological samples.

The CHOP(Phospho Ser30) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage. The antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

With its exceptional performance and reliability, the CHOP(Phospho Ser30) Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of CHOP protein phosphorylation in cellular stress response and apoptosis.