Chk2(Phospho Thr387) Polyclonal Antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutati

The Chk2(Phospho Thr387) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Chk2 protein phosphorylated at threonine 387. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated form of Chk2.

Chk2, also known as checkpoint kinase 2, plays a crucial role in the DNA damage response pathway. Phosphorylation of Chk2 at threonine 387 is a key event in the activation of Chk2 and its subsequent involvement in cell cycle arrest and DNA repair processes. Therefore, the Chk2(Phospho Thr387) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms of DNA damage response and cell cycle regulation.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Chk2 in a wide range of sample types.

The Chk2(Phospho Thr387) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy integration into existing laboratory protocols.

With its exceptional performance and reliability, the Chk2(Phospho Thr387) Polyclonal Antibody is an indispensable tool for researchers investigating the intricate molecular pathways involved in DNA damage response and cell cycle regulation.